Moreover, these autoantibodies showed relatively high positive rates even during stage 0/I disease (55 and 70% with 6 and 17 antibodies, respectively).
Positive rates of 56, 62, 66, 71, and 73% were obtained with 6, 9, 11, 14, and 17 antibodies, respectively, for the overall disease. Combination assays using multiple autoantibodies increased the positive rates based on the number of autoantibodies used. Cutoff values were fixed at mean + 3 standard deviations of serum titers in healthy controls.Īutoantibodies with the highest positive rates were p53 (20%), RalA (14%), HSP70 (12%), and Galectin1 (11%). Therefore, we assessed the possibility of using other serum autoantibodies to increase the positive rates for detecting colorectal cancer.Īutoantibodies against 17 tumor antigens (p53, RalA, HSP70, Galectin1, KM-HN-1, NY-ESO-1, p90, Sui1, HSP40, CyclinB1, HCC-22-5, c-myc, PrxVI, VEGF, HCA25a, p62, and Annexin II) were evaluated in 279 patients with colorectal cancer and 74 healthy controls. PIJAS \U+22051/4"x3/4" CON ARANDELA PLASTICA A CADA 1.50 MTS.Although serum p53 autoantibodies (s-p53-Abs) are induced even in the early stages of colorectal cancer, their positive rate is only approximately 20%.
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